Publications since 2005
  • David D, Hauptmann S, Scherping I, Schuessel K, Keil U, Dröse S, Brandt U, Müller WE, Eckert A, and Götz J (2005) Proteomic and functional analysis reveal a mitochondrial dysfunction in P301L tau transgenic mice, J. Biol. Chem. 280: 23802-23814

  • David D, Hoerndli F, Götz J (2005) Application of Functional Genomics to neurodegenerative disorders. Part I, Transcriptomic and proteomic technology, Prog. Neurobiol. 76: 153-168

  • Hoerndli F, David D, Götz J (2005) Application of Functional Genomics to neurodegenerative disorders. Part II, Application and data integration, Prog. Neurobiol. 76: 169-188

  • Götz J, Chen F (2005) Glyoxalase I and Alzheimer’s disease. In: Research Progress in Alzheimer’s Disease and Dementia (editor: M.-K. Sun; Nova Science Publishers, Inc., New York), in press

  • Götz J, Ittner LM, David DC (2005) Role of the Protein Tau in Alzheimer’s Disease, Drug Disc. Today: Dis. Mech. 2: 395-400

  • Charpantier E*, Wiesner A*, Huh KH*, Ogier R, Holda JC, Allaman G, Raggenbass M, Feuerbach D, Bertrand D, Fuhrer C (2005) α7neuronal acetylcholine receptors are negatively regulated by tyrosine phosphorylation and Src-family kinases. J Neurosci 25(43): 9836-49 (* contributed equally)

  • Götz J, David DC, Ittner L (2005) Impact of β-amyloid on the tau pathology in tau transgenic mouse and tissue culture models. In: Abeta Peptide and Alzheimer’s Disease (editors: Colin C. Barrow and David H. Small, Springer-Verlag London Ltd.), in press

  • Pennanen L, Götz J (2005) Different tau epitopes define Aβ42-mediated tau insolubility, Biochem. Biophys. Res. Commun. 337:1097-101

  • Lang KS, Recher M, Junt T, Navarini A, Harris NL, Freigang S, Odermatt B, Conrad C, Ittner LM, Bauer S, Luther S, Uematsu S, Akira S, Hengartner H & Zinkernagel RM (2005) On the role of Toll-like receptor engagement in conversion of T cell auto-reactivity into overt autoimmune disease. Nature Medicine. 11(2):138-45

  • Ittner LM, Wurdak H, Lang KS, Leveen P, Suter U, Fischer JA, Karlsson S, Born W & Sommer L (2005) Inactivation of TGFb signalling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome. Genes & Dev. 19(5):530-5 (selected as ‘Research Highlight’: Pearson H (2005) DiGeorge mice. Nature. 434(7030):156)

  • Ittner LM, Koller D, Muff R, Fischer JA & Born W (2005) The N-terminal Extracellular Domain 23 to 60 of the Calcitonin Receptor-Like Receptor in Chimeras with the Parathyroid Hormone Receptor Mediates Association with Receptor-Activity-Modifying Protein 1. Biochemistry. 44:5749-54

  • Kleber M, Lee HY, Wurdak H, Buchstaller J, Riccomagno MM, Ittner LM, Suter U, Epstein DJ & SommerL (2005) Neural Crest Stem Cell Maintenance by Combinatorial Wnt and BMP Signalling. J Cell Biol. 169:309-20

  • Kelm JM, Diaz-Bustamante C, Ehler E, Guenter CI, Hoerstrup SP, Djonov V, Ittner LM & Fussenegger M (2005) VEGF Profiling and Angiogenesis in Human Microtissues. J Biotechnol.118:213-29

  • Ittner LM, Wurdak H, Schwerdtfeger K, Kunz T, Leveen P, Hjalt TA, Suter U, Karlsson S, Born W & Sommer L (2005) Compound developmental eye disorders upon TGFβ signal inactivation in neural crest stem cells. J Biol.4(3):11

  • Pennanen L, Wolfer DP, Nitsch RM, Götz J (2006) Impaired reference memory in P301L  tau transgenic mice, Genes, Brain Behav. 5:369-379

  • Pei J-J, An W-L, Zhou X-W, Nishimura T, Norberg J, Benedikz E, Götz J, Winblad B (2006) P70S6 kinase mediated tau phosphorylation and synthesis, FEBS Letters 580: 107-114

  • Kulic L, Kurosinski P, Chen F, Tracy J, Mohajeri H, Li H, Nitsch RM, Götz J (2006) Active immunization trial in Aβ42-injected P301L tau transgenic mice, Neurobiol. Dis. 22: 50-56

  • Tam CW, Husmann K, Lazar Z, Clark NC, Ittner LM, Götz J, Grant AD, Sugden D, McFadzean I, Fischer JA, Born W, Brain SD (2006) Enhanced vascular responses to adrenomedullin in mice overexpressing receptor activity-modifying protein 2., Circulation Res. 98: 62-70

  • Götz J, Ittner L, Kins S (2006) Do axonal defects in tau and APP transgenic animals model axonopathy in Alzheimer’s disease?, J. Neurochem., in press (accepted March 24, 2006)

  • Schild A, Isenmann S, Tanimoto N, Tonagel F, Seliger MW, Ittner LM, Kretz A, Ogris E, Götz J (2006) Impaired development of the Harderian gland in mutant protein phosphatase 2A transgenic mice, Mech. Dev. 123: 362-371

  • Schild A, Ittner LM, Götz J (2006) Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice, Biochem. Biophys. Res. Commun. 343: 1171-1178

  • Wiesner A, Fuhrer C (2006) Regulation of nicotinic acetylcholine receptors by tyrosine kinases in the peripheral and central nervous system: same players, different roles. CMLS in press

  • Götz J, Ittner LM, Schonrock N (2006) Alzheimer’s Disease and Frontotemporal Dementia – Prospects of a tailored therapy?, Med.J.Aust., in press

  • Schild A, Schmidt K, Lim Y-A, Hemmings BA, Götz J (2006) Altered levels of PP2A regulatory B/PR55 isoforms indicate role in neuronal differentiation, IntJDevNeurosci., in press

  • Götz J, Et al, (2006) A decade of tan transgenic animal models and beyond, Brain Pathol., in press

  • Exner, V., Taranto, P., Schonrock, N., Walser, M., Gruissem, W., and Hennig, L. (2006) Chromatin assembly factor CAF-1 is required for cellular differentiation during plant development. Development (in press)

  • Schonrock, N., Bouveret, R., Leroy, O., Borghi, L., Kohler, C., Gruissem, W. and Hennig, L. (2006) Polycomb-group proteins repress the floral activator AGL19 in the FLC-independent vernalization pathway. Genes Dev. 20(12):1667-1678

  • Bouveret, R., Schonrock, N., Gruissem, W. and Hennig, L. (2006) Regulation of flowering time by Arabidopsis MSI1. Development 133(9):1693-1702

  • Schonrock, N., Exner, V., Probst, A., Gruissem, A. and Hennig, L. (2006) Functional genomic analysis of CAF-1 mutants in Arabidopsis thaliana. J. Biol. Chem. 281(14):9560-8

  • Stanescu D, Iseli HP, Schwerdtfeger K, Ittner LM, Reme CE, Hafezi F (2006) Continuous expression of the homeobox gene Pax6 in the ageing human retina. Eye. in press (Oct 05)

  • Kelm JM, Djonov V, Ittner LM, Born W, Hoerstrup SP & Fussenegger M (2006) Design of Custom-Shaped Vascularized Tissues Using Microtissue Spheroids as Minimal Building Units. Tissue Engineering. in press (Oct 05)

  • Kelm JM, Djonov V, Hoerstrup SP, Guenter CI, Ittner LM, Greve F, Hierlemann A, Perriard JC, Ehler E & Fussenegger M (2006) Improved Tissue-Transplant Fusion and Vascularization of Myocardial Micro- and Macrotissues Implanted into Chicken Embryos and Rats. Tissue Engineering. in press (Dec 05)

Publications since 2004
  • Martens E, Stevens I, Janssens V, Vermeesch J, Götz J, Goris J, van Hoof C (2004) Genomic organization, chromosomal localization, tissue distribution and developmental regulation of the PR61/B’ regulatory subunits of Protein Phosphatase 2A in mice, J. Mol. Biol. 336: 971-986 Impact factor: 5.359

  • Götz J, Streffer JR, David D, Schild A, Hoerndli F, Pennanen L, Kurosinski P, Chen F (2004) Transgenic animal models of Alzheimer’s disease and related disorders: Histopathology, behavior and therapy, Mol. Psychiatr. 9: 664-683 [cover image][recommended by AlzForum] Impact factor: 6.900

  • Pennanen L, Welzl H, D’Adamo P, Nitsch RM, Götz J (2004) Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice, Neurobiol. Dis. 15: 500-509 Impact factor: 5.153

  • Rauer M, Götz J, Schuppli D, Staeheli P, Hausmann J (2004) Transgenic mice expressing the nucleoprotein of Borna disease virus (BDV) in neurons and astrocytes have decreased susceptibility to homotypic infection and BDV-induced disease, J. Virol. 78: 3621-3632. Impact factor: 5.241

  • Chen F, Wollmer A, Hoerndli F, Münch G, Kuhla B, Rogaev EI, Tsolaki M, Papassotiropoulos A, Götz J (2004) Role for glyoxalase I in Alzheimer’s disease, Proc. Natl. Acad. Sci. USA 101: 7687-7692 Impact factor: 10.260

  • Chen F, David D, Ferrari A, Götz J (2004) Posttranslational modifications of tau – Role in human tauopathies and modelling in transgenic animal models, Current Drug Targets 5: 503-315 Impact factor: 3.710

  • Götz J, Schild A, Hoerndli F, Pennanen L (2004) Alzheimer’s disease: A challenge for baptists and tauists, Int. J. Dev. Neurosci. 22: 453-465 Impact factor: 2.284

  • Hoerndli F, Toigo M, Schild A, Götz J, Day P (2004) Reference genes identified in SH-SY5Y cells using custom-made gene arrays with validation by quantitative PCR, Anal. Biochem. 335: 30-41 Impact factor: 2.370

  • Koller D, Ittner LM, Muff R, Husmann K, Fischer JA & Born W (2004) Selective inactivation of adrenomedullin over calcitonin gene-related peptide receptor function by the deletion of amino acids 14-20 of the mouse calcitonin-like receptor. J Biol Chem. 279(19):20387-91 Impact factor: 7.666

  • Ittner LM, Luessi F, Koller D, Born W, Fischer JA & Muff R (2004) Aspartate(69) of the calcitonin-like receptor is required for its functional expression together with receptor-activity-modifying proteins 1 and -2. Biochem Biophys Res Commun. 319(4):1203-9 Impact factor: 2.904

  • Green JD, Goldsbury C, Kistler J, Cooper GJ, Aebi U (2004). Human amylin oligomer growth and fibril elongation define two distinct phases in amyloid formation. J Biol Chem 279(13):12206-12.

  • Green JD, Kreplak L, Goldsbury C, Li Blatter X, Stolz M, Cooper GS, Seelig A, Kistler J, Aebi U. (2004) Atomic force microscopy reveals defects within mica supported lipid bilayers induced by the amyloidogenic human amylin peptide. J Mol Biol. 342(3):877-87.

  • Dixon G, Garrick T, Whiteman I, Sarris M, Sithamparanathan S, Harper CG (2004) Characterization of gabaergic neurons within the human medial mamillary nucleus, Neuroscience 127(2): 365-372

  • David D, Hauptmann S, Scherping I, Schuessel K, Keil U, Dröse S, Brandt U, Müller WE, Eckert A, Götz J (2005) Proteomic and functional analysis reveal a mitochondrial dysfunction in P301L tau transgenic mice, J. Biol. Chem. 280: 23802-23814 Impact factor: 7.666

  • David D, Hoerndli F, Götz J (2005) Application of Functional Genomics to neurodegenerative disorders. Part I, Transcriptomic and proteomic technology, Prog. Neurobiol. 76: 153-168 Impact factor: 11.933

  • Hoerndli F, David D, Götz J (2005) Application of Functional Genomics to neurodegenerative disorders. Part II, Application and data integration, Prog. Neurobiol. 76: 169-188 Impact factor: 11.933

  • Götz J, Ittner LM, David DC (2005) Role of the Protein Tau in Alzheimer’s Disease, Drug Disc. Today: Dis. Mech. 2: 395-400 Impact factor: N.A.

  • Pennanen L, Götz J (2005) Different tau epitopes define Aß42-mediated tau insolubility, Biochem. Biophys. Res. Commun. 337:1097-101 Impact factor: 2,904

  • Goldsbury C, Frey P, Olivieri V, Aebi U, Muller SA. Multiple assembly pathways underlie amyloid-beta fibril polymorphisms. J Mol Biol 2005;352(2):282-98.

  • Goldsbury C, Green JD (2005). Time-lapse atomic force microscopy in the characterization of amyloid-like fibril assembly and oligomeric intermediates. Methods Mol Biol. 299:103-28.

  • Lang KS, Recher M, Junt T, Navarini A, Harris NL, Freigang S, Odermatt B, Conrad C, Ittner LM, Bauer S, Luther S, Uematsu S, Akira S, Hengartner H & Zinkernagel RM (2005) On the role of Toll-like receptor engagement in conversion of T cell auto-reactivity into overt autoimmune disease. Nature Medicine. 11(2):138-45 Impact factor: 31.223

  • Wurdak H*, Ittner LM*, Lang KS, Leveen P, Suter U, Fischer JA, Karlsson S, Born W & Sommer L (2005) Inactivation of TGF? signalling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome. Genes & Dev. 19(5):530-5 [selected as ‘Research Highlight’: Pearson H (2005) DiGeorge mice. Nature. 434(7030):156)] * shared first authorship Impact factor: 16.385

  • Ittner LM, Koller D, Muff R, Fischer JA & Born W (2005) The N-terminal Extracellular Domain 23 to 60 of the Calcitonin Receptor-Like Receptor in Chimeras with the Parathyroid Hormone Receptor Mediates Association with Receptor-Activity-Modifying Protein 1. Biochemistry. 44:5749-54 Impact factor: 4.008

  • Kleber M, Lee HY, Wurdak H, Buchstaller J, Riccomagno MM, Ittner LM, Suter U, Epstein DJ & Sommer L (2005) Neural Crest Stem Cell Maintenance by Combinatorial Wnt and BMP Signalling. J Cell Biol. 169:309-20 Impact factor: 11.602

  • Kelm JM, Diaz-Bustamante C, Ehler E, Guenter CI, Hoerstrup SP, Djonov V, Ittner LM & Fussenegger M (2005) VEGF Profiling and Angiogenesis in Human Microtissues. J Biotechnol.118:213-29 Impact factor: 2.323

  • Ittner LM, Wurdak H, Schwerdtfeger K, Kunz T, Leveen P, Hjalt TA, Suter U, Karlsson S, Born W & Sommer L (2005) Compound developmental eye disorders upon TGFß ?signal inactivation in neural crest stem cells. J Biol. 4(3):11 [noted as highly accessed publication] Impact factor: N.A.

  • Charpantier E*, Wiesner A*, Huh KH*, Ogier R, Hoda JC, Allaman G, Raggenbass M, Feuerbach D, Bertrand D, Fuhrer C (2005) a7neuronal acetylcholine receptors are negatively regulated by tyrosine phosphorylation and Src-family kinases. J Neurosci. 25(43):9836-49 (*contributed equally) Impact factor: 7.506

  • Götz J, Chen F (2006) Glyoxalase I and Alzheimer’s disease (chapter 10). In: Research Progress in Alzheimer’s Disease and Dementia (editor: M.-K. Sun; Nova Science Publishers, Inc., New York), ISBN 1-59454-949-4 Impact factor: N.A.

  • Schild A, Schmidt K, Lim Y-A, Ke Y, Ittner LM, Hemmings BA, Götz J (2006) Altered levels of PP2A regulatory B/PR55 isoforms indicate role in neuronal differentiation, IntJDevNeurosci. 24: 437-443 Impact factor: 2.089

  • Schild A, Isenmann S, Tanimoto N, Tonagel F, Seliger MW, Ittner LM, Kretz A, Ogris E, Götz J (2006) Impaired development of the Harderian gland in mutant protein phosphatase 2A transgenic mice, Mech. Dev. 123: 362-371 Impact factor: 3.263

  • Schild A, Ittner LM, Götz J (2006) Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice, Biochem. Biophys. Res. Commun. 343: 1171-1178 Impact factor: 2,904

  • Pennanen L, Wolfer DP, Nitsch RM, Götz J (2006) Impaired reference memory and increased exploratory behavior in P301L tau transgenic mice, Genes, Brain Behav. 5:369-379 Impact factor: 3,846

  • Götz J, Ittner LM, Schonrock N (2006) Alzheimer’s Disease and Frontotemporal Dementia – Prospects of a tailored therapy?, Med. J. Aust. 185: 381-384 Impact factor: 2.127

  • Götz J, Ittner L, Kins S (2006) Do axonal defects in tau and APP transgenic animals model axonopathy in Alzheimer’s disease?, J. Neurochem. 98: 993-1006 Impact factor: 4.824

  • Kulic L, Kurosinski P, Chen F, Tracy J, Mohajeri MH, Li H, Nitsch RM, Götz J (2006) Active immunization trial in Aß42-injected P301L tau transgenic mice, Neurobiol. Dis. 22: 50-56 Impact factor: 5.153

  • Tam CW, Husmann K, Clark NC, Clark JE, Lazar Z, Ittner LM, Götz J, Douglas G, Grant AD, Sugden D, Poston L, Poston R, McFadzean I, Marber MS, Fischer JA, Born W, Brain SD (2006) Enhanced vascular responses to adrenomedullin in mice overexpressing receptor activity-modifying protein 2., Circulation Res. 98: 262-70 Impact factor: 9.972

  • Pei J-J, An W-L, Zhou X-W, Nishimura T, Norberg J, Benedikz E, Götz J, Winblad B (2006) P70S6 kinase mediates tau phosphorylation and synthesis, FEBS Letters 580: 107-114 Impact factor: 3.720

  • David DC, Ittner LM, Gehrig P, Nergenau D, Shepherd C, Halliday G, Götz J (2006) ß-Amyloid treatment of two complementary P301L tau-expressing Alzheimer’s disease models reveals similar deregulated cellular processes, Proteomics 6: 6566-6577 Impact factor: 6.088

  • Kelm JM, Ittner LM, Born W, Djonov V & Fussenegger M (2006) Self-Assembly of Sensory Neurons Into Ganglia-Like Microtissues. J Biotechnol. 121(1):86-101 Impact factor: 2.323

  • Kelm JM, Djonov V, Ittner LM, Born W, Hoerstrup SP & Fussenegger M (2006) Design of Custom-Shaped Vascularized Tissues Using Microtissue Spheroids as Minimal Building Units. Tissue Engineering 12: 2151-60 Impact factor: 3.143

  • Kelm JM, Djonov V, Hoerstrup SP, Guenter CI, Ittner LM, Greve F, Hierlemann A, Perriard JC, Ehler E & Fussenegger M (2006) Improved Tissue-Transplant Fusion and Vascularization of Myocardial Micro- and Macrotissues Implanted into Chicken Embryos and Rats. Tissue Engineering. 10:201-14 Impact factor: 3.143

  • Goldsbury C, Mocanu MM, Thies E, Kaether C, Haass C, Keller P, Biernat J, Mandelkow E, Mandelkow E-M. (2006) Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides. Traffic 7(7):873-88 Impact factor: 6.400

  • Baer K, Burli T, Huh KH, Wiesner A, Erb-Vogtli S, Gockeritz-Dujmovic D, Moransard M, Nishimune A, Rees MI, Henley JM, Fritschy JM, Fuhrer C (2006) PICK1 interacts with a7 neuronal nicotinic acetylcholine receptors and controls their clustering. Mol Cell Neurosci. 35:339-55 Impact factor: 4.641

  • Wiesner A, Fuhrer C (2006) Regulation of nicotinic acetylcholine receptors by tyrosine kinases in the peripheral and central nervous system: same players, different roles. Cell Mol Life Sci. Dec; 63(23):2818-28. Impact factor: N.A.

  • Wiesner A (2006) Functional regulation of the alpha7 nicotinic acetylcholine receptor by protein interaction and tyrosine phosphorylation. Wiesner A, dissertation at the Swiss Federal Institute of Technology Zürich (ETH) Impact factor: N.A.

  • Burke D, Hickie I, Breakspear M, Götz J (2007) Is there good news about dementia? Possibilities for the prevention and treatment of cognitive impairment and dementia, Brit. J. Psychiatry, in press (16 Dec accepted) Impact factor: 4.956

  • Götz J, Deters N, Doldissen A, Ke Y, Bokhari L, Wiesner A, Schonrock N, Ittner LM (2006) A decade of tau transgenic animal models and beyond, Brain Pathol., 17 (1): 91-103 Impact factor: 4.041

  • Exner, V., Taranto, P., Schonrock, N., Walser, M., Gruissem, W., and Hennig, L. (2006) Chromatin assembly factor CAF-1 is required for cellular differentiation during plant development. Development 133(21):4163-72. Impact factor: 7.603

  • Schonrock, N., Bouveret, R., Leroy, O., Borghi, L., Kohler, C., Gruissem, W. and Hennig, L. (2006) Polycomb-group proteins repress the floral activator AGL19 in the FLC-independent vernalization pathway. Genes Dev. 20(12):1667-1678 Impact factor: 15.610

  • Bouveret, R., Schonrock, N., Gruissem, W. and Hennig, L. (2006) Regulation of flowering time by Arabidopsis MSI1. Development 133(9):1693-1702 Impact factor: 7.603

  • Schonrock, N., Exner, V., Probst, A., Gruissem, A. and Hennig, L. (2006) Functional genomic analysis of CAF-1 mutants in Arabidopsis thaliana. J. Biol. Chem. 281(14):9560-8 Impact factor: 7.666

  • Moussa CE, Rae C, Bubb WA, Griffin JL, Deters NA, Balcar VJ (2007) Inhibitors of glutamate transport modulate distinct patterns in brain metabolism, J Neurosci Res 85(2):342-50 Impact factor: 3.239

  • Götz J, David DC, Ittner L (2007) Impact of ß-amyloid on the tau pathology in tau transgenic mouse and tissue culture models (chapter 12/16). In: Celebrating a Century of Research. Abeta Peptide and Alzheimer’s Disease (editors: Colin C. Barrow and David H. Small, Springer-Verlag London Ltd.), ISBN-13: 978-1-85233-961-6 Impact facor: N.A.

  • Ittner LM, Götz J (2007) Generation of transgenic mice by pronuclear injection, Nature Protocols 2(5): 1206-1215 Impact factor: N.A.

  • Hoerndli F, Pelech S, Papassotiropoulos, Götz J (2007) A? treatment and P301L tau expression in an Alzheimer’s disease tissue culture model act synergistically to promote aberrant cell cycle re-entry, Eur. J. Neurosci., in press (acc May 9, 2007) Impact factor: 3.949

  • Ittner LM, Fath T, Götz J (2007) Primary neuronal cultures, Nature Protocols, invited contribution Impact factor: N.A.

  • Baur K, Rauer M, Götz J, Hausmann J, Staeheli, P (2007) Antiviral CD8 T cells recognize Borna disease virus antigen transgenically expressed in either neurons or astrocytes, J. Virol., in revision Impact factor: 5.178

  • Goldsbury C, Thies E., Konzack S., Mandelkow E-M. (2007) Quantification of APP and tau for the study of axonal traffic pathways. J. Neurosci 27(13):3357-63. Impact factor: 7.506

  • Stanescu D, Iseli HP, Schwerdtfeger K, Ittner LM, Reme CE, Hafezi F (2007) Continuous expression of the homeobox gene Pax6 in the ageing human retina. Eye. 21:90-93 Impact factor: 1.496

  • Kunz TH, Mueller-Steiner S, Schwerdtfeger K, Kleinert P, Troxler H, Kelm JM, Ittner LM, Fischer JA, Born W. (2007) Interaction of receptor-activity-modifying protein1 with tubulin. Biochim Biophys Acta. Apr 11 [Epub ahead of print]