Director, Alzheimer's and Parkinson's Disease Laboratory
Brain and Mind Research Institute
University of Sydney
100 Mallett St
Camperdown, NSW 2050

Room: R309
Phone Office: +61-2-9351-0789 or 0799 (reception)
Phone Lab: +61-2-9351-0875
Fax: +61-2-9351-0652
E-mail: jgoetz@med.usyd.edu.au

Publications

• Cho KWY, Götz J, Fritz A, Hardwicke J, DeRobertis, EM (1988) Differential utilization of the same reading frame in a Xenopus homeobox gene encodes two related proteins sharing the same DNA-binding specificity. EMBO J. 7: 139-149 Impact factor: 13.973
• Götz J, Eibel H, Köhler G (1990) Non-tolerance and differential susceptibility to diabetes in transgenic mice expressing major histocompatibility class II genes on pancreatic beta cells. Eur. J. Imm. 20: 1677-1683 Impact factor: 5.635
• Hebert JM, Rosenquist T, Götz J, Martin GR (1994) FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations. Cell 78: 1017-1025 Impact factor: 36.242
• Götz J, Probst A, Spillantini MG, Schäfer T, Jakes R, Bürki K, Goedert M (1995) Somatodendritic localisation and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform. EMBO J. 14: 1304-1313 Impact factor: 13.973
• Goedert M, Spillantini MG, Jakes R, Crowther RA, Cohen P, Vanmechelen E, Probst A, Götz J, Bürki K (1995) Molecular dissection of the paired helical filament. In: Recent Advances in Alzheimer's Disease and Related Disorders (K.Iqbal, J.Mortimer, B.Winblad & H.Wisniewski,eds). Wiley and Sons, chapter 54: 493-502 Impact factor: N.A.
• Goedert M, Jakes R, Spillantini MG, Crowther RA, Cohen P, Vanmechelen E, Probst A, Götz J, Bürki K (1995) Tau protein in Alzheimer's disease. Biochem. Soc. Transact. 23: 80-85 Impact factor: 0.964
• Goedert M, Spillantini MG, Jakes R, Crowther RA, Vanmechelen E, Probst A, Götz J, Bürki K, Cohen P (1995) Molecular dissection of the paired helical filament. Neurobiology of Aging 16: 325-334 Impact factor: 3.399
• Li ZW, Stark G, Götz J, Rülicke T, Müller U, Weissmann C (1996) Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombinatiton in embryonic stem cells. Proc. Natl. Acad. Sci. USA 93: 6158-6162 Impact factor: 10.260
• Shmerling D, Hegyi I, Fischer M, Blättler T, Brandner T, Götz J, Rülicke T, Flechsig E, Cozzio A, von Mering C, Hangartner C, Aguzzi A, Weissmann C (1998) Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. Cell 93: 203-214 Impact factor: 36.242
• Götz J, Probst A, Ehler E, Hemmings B, Kues W (1998) Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Cα. Proc. Natl. Acad. Sci. USA 95: 12370-12375 Impact factor: 10.260
• Götz J, Kues W (1999) The role of protein phosphatase 2A catalytic subunit Cα in embryogenesis: Evidence from sequence analysis and localization studies. Biol. Chem. 380: 1117-1120 [cover image] Impact factor: 3.356
• Probst A, Götz J, Wiederhold KH, Tolnay M, Mistl C, Jaton AL, Hong M, Ishihara T, Lee VM-Y, Trojanowski JQ, Jakes R, Crowther RA, Spillantini MG, Bürki K, Goedert M (2000) Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein. Acta Neuropathol. 99: 469-481 Impact factor: 2.402
• Götz J, Probst A, Mistl C, Nitsch RM, Ehler E (2000) Distinct role of protein phosphatase 2A subunit Cα in the regulation of E-cadherin and β-catenin during development. Mech. Dev. 93: 83-93 Impact factor: 5.049
• Götz J, Barmettler R, Ferrari A, Goedert M, Probst A, Nitsch RM (2000) In vivo analysis of wild-type and FTDP-17 tau mutant mice. Ann. N.Y.Acad. Sci. 920: 126-133 Impact factor: 0.964
• Ferrari A, Ehler E, Nitsch RM, Götz J (2000) Immature human NT2 cells grafted into mouse brain differentiate into neuronal and glial cell types. FEBS Letters 486: 121-125 Impact factor: 3.720
• Götz J, Tolnay M, Barmettler R, Ferrari A, Bürki K, Goedert M, Probst A, Nitsch RM (2001) Human tau transgenic mice. Towards an animal model for neuro- and glialfibrillary lesion formation. Adv. Exp. Med. Biol. 487: 71-83 Impact factor: 0.513
• Götz J, Chen F, Barmettler R, Nitsch RM (2001) Tau filament formation in transgenic mice expressing P301L tau. J. Biol. Chem. 276: 529-534 Impact factor: 7.666
• Götz J (2001) Tau and transgenic animal models, Brain Res. Rev. 35: 266-286 Impact factor: 6.651
• Götz J, Tolnay M, Barmettler R, Chen F, Probst A, Nitsch RM (2001) Oligodendroglial tau filament formation in transgenic mice expressing G272V tau, Eur. J. Neurosci. 13: 2131-2140 Impact factor: 4.163
• Götz J, Nitsch RM (2001) Compartmentalized tau hyperphosphorylation and increased levels of kinases in transgenic mice, Neuroreport 12: 2007-2016 Impact factor: 2.682
• Götz J (2001) Tau be or not tau be Tauopathien und transgene Tiermodelle, Neuroforum, 3/01: 93-101 Impact factor: N.A.
• Götz J, Chen F, Nitsch RM (2001) Interactions of beta-amyloid with the formation of neurofibrillary tangles in transgenic mice. In: Mapping the Progress of Alzheimer's and Parkinson's Disease (editors: Y.Mizuno, A. Fisher, I. Hanin; Kluver Academic/Plenum Publishers) Adv. in Beh. Biol. 51: 139-144 Impact factor: N.A.
• Götz J, Chen F, van Dorpe J, Nitsch RM (2001) Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Abeta42 fibrils, Science 293: 1491-1495 Impact factor: 28.956
• Kins S, Crameri A, Evans DRH, Hemmings BA, Nitsch RM, Götz J (2001) Reduced PP2A activity induces abnormal phosphorylation and compartmentalization of tau in transgenic mice, J. Biol. Chem. 276: 38193-38200 Impact factor: 7.666
• Kurosinski P, Guggisberg M, Götz J (2002) Alzheimer's disease and Parkinson's disease - overlapping or synergistic pathologies? (Research News), Trends Mol. Med. 8: 3-5 Impact factor: 5.193
• Kurosinski P, Götz J (2002) Glial cells under physiologic and pathologic conditions (Basic science seminar in neurology), Arch. Neurol. 59: 1524-1528 Impact factor: 4.393
• Götz J (2002) Die Alzheimer'sche Krankheit: Wechselwirkung zwischen Tau und β-Amyloid, Festschrift aus Anlass der Verleihung des Georg Friedrich Götz-Preises 2002, p. 1-17 Impact factor: N.A.
• Schmidt K, Kins S, Schild A, Nitsch RM, Hemmings B, Götz J (2002) Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A, Eur. J. Neurosci. 16: 2039-2048 Impact factor: 4.163
• Götz J, Schild A (2003) Transgenic and knockout models of PP2A, Methods Enzymol. 366: 390-403 Impact factor: 2.340
• Streffer JR, Papassotiropoulos A, Kurosinski P, Signorell A, Wollmer MA, Tsolaki M, Iakovidou V, Hörndli F, Bosset J, Götz J, Nitsch RM, Hock C (2003) Saitohin gene is not associated with Alzheimer's disease, J. Neurol. Neurosur. Ps. 74: 362-363 Impact factor: 3.024
• Chen F, Ferrari A, Schild A, Kurosinski P, David D, Hoerndli F, Pennanen L, Kins S, van Dorpe J, Nitsch RM, Götz J (2003) Amyloid-induced neurofibrillary tangle formation. In: Alzheimer's disease and related disorders: Research advances (editors: K. Iqbal, B. Winblad; Ana Aslan International Foundation), p. 343-354 (chapter 30) Impact factor: N.A.
• Flechsig E, Hegyi I, Leimeroth R, Zuniga A, Rossi D, Cozzio A, Schwarz P, Rülicke R, Götz J, Aguzzi A, Weissmann C (2003) Expression of truncated PrP targeted to Purkinje cells of PrP knockout mice causes Purkinje cell death and ataxia, EMBO J. 22: 3095-3101 Impact factor: 13.973
• Kins S, Kurosinski P, Nitsch RM, Götz J (2003) Activation of the ERK and JNK signaling pathways caused by neuron specific inhibition of PP2A in transgenic mice, Am. J. Pathol. 163: 833-843 Impact factor: 7.103
• Ferrari A, Hoerndli F, Baechi T, Nitsch RM, Götz J (2003) β-Amyloid induces PHF-like tau filaments in tissue culture, J. Biol. Chem. 278, 40162-40168 Impact factor: 7.666
• Martens E, Stevens I, Janssens V, Vermeesch J, Götz J, Goris J, van Hoof C (2004) Genomic organization, chromosomal localization, tissue distribution and developmental regulation of the PR61/B' regulatory subunits of Protein Phosphatase 2A in mice, J. Mol. Biol. 336: 971-986 Impact factor: 5.359
• Götz J, Streffer JR, David D, Schild A, Hoerndli F, Pennanen L, Kurosinski P, Chen F (2004) Transgenic animal models of Alzheimer's disease and related disorders: Histopathology, behavior and therapy, Mol. Psychiatr. 9: 664-683 Impact factor: 6.900
• Pennanen L, Welzl H, D'Adamo P, Nitsch RM, Götz J (2004) Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice, Neurobiol. Dis. 15: 500-509 Impact factor: 5.153
• Rauer M, Götz J, Schuppli D, Staeheli P, Hausmann J (2004) Transgenic mice expressing the nucleoprotein of Borna disease virus (BDV) in neurons and astrocytes have decreased susceptibility to homotypic infection and BDV-induced disease, J. Virol. 78: 3621-3632. Impact factor: 5.241
• Chen F, Wollmer A, Hoerndli F, Münch G, Kuhla B, Rogaev EI, Tsolaki M, Papassotiropoulos A, Götz J (2004) Role for glyoxalase I in Alzheimer's disease, Proc. Natl. Acad. Sci. USA 101: 7687-7692 Impact factor: 10.260
• Chen F, David D, Ferrari A, Götz J (2004) Posttranslational modifications of tau - Role in human tauopathies and modelling in transgenic animal models, Current Drug Targets 5: 503-315 Impact factor: 3.710
• Götz J, Schild A, Hoerndli F, Pennanen L (2004) Alzheimer's disease: A challenge for baptists and tauists, Int. J. Dev. Neurosci. 22: 453-465 Impact factor: 2.284
• Hoerndli F, Toigo M, Schild A, Götz J, Day P (2004) Reference genes identified in SH-SY5Y cells using custom-made gene arrays with validation by quantitative PCR, Anal. Biochem. 335: 30-41 Impact factor: 2.370
• David D, Hauptmann S, Scherping I, Schuessel K, Keil U, Dröse S, Brandt U, Müller WE, Eckert A, and Götz J (2005) Proteomic and functional analysis reveal a mitochondrial dysfunction in P301L tau transgenic mice, J. Biol. Chem. 280: 23802-23814 Impact factor: 7.666
• David D, Hoerndli F, Götz J (2005) Application of Functional Genomics to neurodegenerative disorders. Part I, Transcriptomic and proteomic technology, Prog. Neurobiol. 76: 153-168 Impact factor: 11.933
• Hoerndli F, David D, Götz J (2005) Application of Functional Genomics to neurodegenerative disorders. Part II, Application and data integration, Prog. Neurobiol. 76: 169-188 Impact factor: 11.933
• Götz J, Chen F (2005) Glyoxalase I and Alzheimer's disease. In: Research Progress in Alzheimer's Disease and Dementia (editor: M.-K. Sun; Nova Science Publishers, Inc., New York), in press Impact factor: N.A.
• Götz J, Ittner LM, David DC (2005) Role of the Protein Tau in Alzheimer's Disease, Drug Disc. Today: Dis. Mech. 2: 395-400 Impact factor: N.A.
• Götz J, David DC, Ittner L (2005) Impact of β-amyloid on the tau pathology in tau transgenic mouse and tissue culture models. In: Abeta Peptide and Alzheimer's Disease (editors: Colin C. Barrow and David H. Small, Springer-Verlag London Ltd.), in press Impact factor: N.A.
• Pennanen L, Götz J (2005) Different tau epitopes define Aβ₄₂-mediated tau insolubility, Biochem. Biophys. Res. Commun. 337:1097-101 Impact factor: 2,904
• Pennanen L, Wolfer DP, Nitsch RM, Götz J (2006) Impaired reference memory in P301L tau transgenic mice, Genes, Brain Behav. 5:369-379 Impact factor: 3,846
• Pei J-J, An W-L, Zhou X-W, Nishimura T, Norberg J, Benedikz E, Götz J, Winblad B (2006) P70S6 kinase mediated tau phosphorylation and synthesis, FEBS Letters 580: 107-114 Impact factor: 3.720
• Kulic L, Kurosinski P, Chen F, Tracy J, Mohajeri H, Li H, Nitsch RM, Götz J (2006) Active immunization trial in Aβ42-injected P301L tau transgenic mice, Neurobiol. Dis. 22: 50-56 Impact factor: 5.153
• Tam CW, Husmann K, Lazar Z, Clark NC, Ittner LM, Götz J, Grant AD, Sugden D, McFadzean I, Fischer JA, Born W, Brain SD (2006) Enhanced vascular responses to adrenomedullin in mice overexpressing receptor activity-modifying protein 2., Circulation Res. 98: 62-70 Impact factor: 9.972
• Götz J, Ittner L, Kins S (2006) Do axonal defects in tau and APP transgenic animals model axonopathy in Alzheimer's disease?, J. Neurochem., in press (accepted March 24, 2006) Impact factor: 4.824
• Schild A, Isenmann S, Tanimoto N, Tonagel F, Seliger MW, Ittner LM, Kretz A, Ogris E, Götz J (2006) Impaired development of the Harderian gland in mutant protein phosphatase 2A transgenic mice, Mech. Dev. 123: 362-371 Impact factor: 3.263
• Schild A, Ittner LM, Götz J (2006) Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice, Biochem. Biophys. Res. Commun. 343: 1171-1178 Impact factor: 2,904
• Götz J, Ittner LM, Schonrock N (2006) Alzheimer's Disease and Frontotemporal Dementia - Prospects of a tailored therapy?, Med.J.Aust., in press Impact factor: 2.127
• Schild A, Schmidt K, Lim Y-A, Hemmings BA, Götz J (2006) Altered levels of PP2A regulatory B/PR55 isoforms indicate role in neuronal differentiation, IntJDevNeurosci., in press Impact factor: 2.089
• Götz J, et al (2006) A decade of transgenic animal modules and beyond, Brain Pathol., in press Impact factor: 4.041