BMRI Dr. Lars Ittner
 
  Dr. Lars Ittner Group Leader, MD

Alzheimer's and Parkinson's Disease Laboratory
Brain and Mind Research Institute
University of Sydney
100 Mallett St
Camperdown, NSW 2050

Room: R308
Phone Office: +61-2-9351-0845
Phone Lab: +61-2-9351-0875
Fax: +61-2-9351-0652 E-mail: littner@med.usyd.edu.au

Education:

1994-2001Medical Degree, University of Ulm, Germany
2001-2002Doctor of Medicine, Research Laboratory for Calcium Metabolism, University of Zurich, Switzerland


Professional Experience:

2002-2003 Postgraduate Course in Experimental Medicine and Biology, University of Zurich, Switzerland
2003-2005Postdoctoral Fellow, Research Laboratory for Calcium Metabolism, University of Zurich, Switzerland
2005-2007Senior Postdoctoral Fellow, Alzheimer’s and Parkinson’s Disease Laboratory, Brain & Mind Research Institute, University of Sydney, Australia
Since 2008Group leader, Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Australia

Publications:
  • Ittner LM, Born W, Rau B, Steinbach G & Fischer JA (2002) Circulating procalcitonin and cleavage products in septicaemia compared with medullary thyroid carcinoma. Eur J Endocrinol. 147:727-31 Impact factor: 3.140
  • Koller D, Ittner LM, Muff R, Husmann K, Fischer JA & Born W (2004) Selective inactivation of adrenomedullin over calcitonin gene-related peptide receptor function by the deletion of amino acids 14-20 of the mouse calcitonin-like receptor. J Biol Chem. 279(19):20387-91 Impact factor: 7.666
  • Ittner LM, Luessi F, Koller D, Born W, Fischer JA & Muff R (2004) Aspartate(69) of the calcitonin-like receptor is required for its functional expression together with receptor-activity-modifying proteins 1 and -2. Biochem Biophys Res Commun. 319(4):1203-9 Impact factor: 2.904
  • Lang KS, Recher M, Junt T, Navarini A, Harris NL, Freigang S, Odermatt B, Conrad C, Ittner LM, Bauer S, Luther S, Uematsu S, Akira S, Hengartner H & Zinkernagel RM (2005) On the role of Toll-like receptor engagement in conversion of T cell auto-reactivity into overt autoimmune disease. Nature Medicine. 11(2):138-45 Impact factor: 31.223
  • Ittner LM, Wurdak H, Lang KS, Leveen P, Suter U, Fischer JA, Karlsson S, Born W & Sommer L (2005) Inactivation of TGFβ signalling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome. Genes & Dev. 19(5):530-5 (selected as ‘Research Highlight’: Pearson H (2005) DiGeorge mice. Nature. 434(7030):156) Impact factor: 16.385
  • Ittner LM, Koller D, Muff R, Fischer JA & Born W (2005) The N-terminal Extracellular Domain 23 to 60 of the Calcitonin Receptor-Like Receptor in Chimeras with the Parathyroid Hormone Receptor Mediates Association with Receptor-Activity-Modifying Protein 1. Biochemistry. 44:5749-54 Impact factor: 4.008
  • Kleber M, Lee HY, Wurdak H, Buchstaller J, Riccomagno MM, Ittner LM, Suter U, Epstein DJ & SommerL (2005) Neural Crest Stem Cell Maintenance by Combinatorial Wnt and BMP Signalling. J Cell Biol. 169:309-20 Impact factor: 11.602
  • Kelm JM, Diaz-Bustamante C, Ehler E, Guenter CI, Hoerstrup SP, Djonov V, Ittner LM & Fussenegger M (2005) VEGF Profiling and Angiogenesis in Human Microtissues. J Biotechnol.118:213-29 Impact factor: 2.323
  • Ittner LM, Wurdak H, Schwerdtfeger K, Kunz T, Leveen P, Hjalt TA, Suter U, Karlsson S, Born W & Sommer L (2005) Compound developmental eye disorders upon TGFβ signal inactivation in neural crest stem cells. J Biol. 4(3):11 Impact factor: N.A. (noted as highly accessed publication)
  • Kelm JM, Ittner LM, Born W, Djonov V & Fussenegger M (2006) Self-Assembly of Sensory Neurons Into Ganglia-Like Microtissues. J Biotechnol. 121(1):86-101 Impact factor: 2.323
  • Götz J, David DC, Ittner LM (2005) Impact of β-amyloid on the tau pathology in tau transgenic mouse and tissue culture models. In: Abeta Peptide and Alzheimer’s Disease (editors: Colin C. Barrow and David H. Small, Springer-Verlag London Ltd.), in press
  • Tam CW, Husmann K, Lazar Z, Clark NC, Ittner LM, Götz J, Grant AD, Sugden D, McFadzean I, Fischer JA, Born W & Brain SD (2006) Enhanced vascular responses to adrenomedullin in mice overexpressing receptoractivity-modifying protein 2. Circ Res. 98(2):262-70 Impact factor: 9.972
  • Stanescu D, Iseli HP, Schwerdtfeger K, Ittner LM, Reme CE, Hafezi F (2006) Continuous expression of the homeobox gene Pax6 in the ageing human retina. Eye. in press (Oct 05) Impact factor: 1.496
  • Kelm JM, Djonov V, Ittner LM, Born W, Hoerstrup SP & Fussenegger M (2006) Design of Custom-Shaped Vascularized Tissues Using Microtissue Spheroids as Minimal Building Units. Tissue Engineering. in press (Oct 05) Impact factor: 3.143
  • Kelm JM, Djonov V, Hoerstrup SP, Guenter CI, Ittner LM, Greve F, Hierlemann A, Perriard JC, Ehler E & Fussenegger M (2006) Improved Tissue-Transplant Fusion and Vascularization of Myocardial Micro- and Macrotissues Implanted into Chicken Embryos and Rats. Tissue Engineering. in press (Dec 05) Impact factor: 3.143
  • Götz J, Ittner L, Kins S (2006) Do axonal defects in tau and APP transgenic animals model axonopathy in Alzheimer’s disease?, J. Neurochem., in press (accepted March 24, 2006) Impact factor: 4.824
  • Schild A, Isenmann S, Tanimoto N, Tonagel F, Seliger MW, Ittner LM, Kretz A, Ogris E, Götz J (2006) Impaired development of the Harderian gland in mutant protein phosphatase 2A transgenic mice, Mech. Dev. 123: 362-371 Impact factor: 3.263
  • Schild A, Ittner LM, Götz J (2006) Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice, Biochem. Biophys. Res. Commun. 343: 1171-1178 Impact factor: 2,904
  • Götz J, Ittner LM, Schonrock N (2006) Alzheimer’s Disease and Frontotemporal Dementia – Prospects of a tailored therapy?, Med.J.Aust., in press Impact factor: 2.127
 
 
 
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