Publications

  1. Holsinger RMD, Lee JS, Boyd A, Masters CL and Collins SJ. (2006) CSF BACE1 activity is increased in CJD and Alzheimer disease versus other dementias. Neurology, 67:710-712.
  2. White AR, Du T, Laughton KM, Volitakis I, Sharples RA, Hoke DE, Holsinger RMD, Evin G, Cherny RA, Hill AF, Barnham KJ, Li Q-X, Bush AI, Masters CL. (2006) Clioquinol induces metal-dependent degradation of the Alzheimer's disease amyloid beta peptide by up-regulation of matrix metalloproteases. Journal of Biological Chemistry, 281:17670-17680.
  3. Beckman M, Holsinger RMD and Small DH. (2006) Heparin activates β-secretase (BACE1) of Alzheimer's disease and increases autocatalysis of the enzyme. Biochemistry, 45:6703-6714.
  4. George AJ, Holsinger RMD, McLean CA, Tan S-S, Scott HS, Cardamone T, Cappai R, Masters CL and Li Q-X. (2006) Decreased phosphatidylethanolamine binding protein (PEBP) expression correlates with Aβ accumulation in the Tg2576 mouse model of Alzheimer's disease. Neurobiology of Aging, 27(4):614-623. Epub 6 June 2005.
  5. Holsinger RMD, McLean CA, Collins CJ, Masters CL and Evin G. (2004) Increased β-secretase activity in cerebrospinal fluid of Alzheimer's disease subjects. Annals of Neurology, 55(6):898-899.
  6. George AJ, Holsinger RMD, McLean C, Laughton K, Beyreuther K, Evin G, Masters CL and Li Q-X. (2004) APP intracellular domain is increased and soluble Aβ is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer's disease. Neurobiology of Disease, 16:124-132.
  7. Evin G, Xu A, Holsinger RMD, Masters CL and Li Q-X. (2003) Proteolytic processing of the Alzheimer's Disease amyloid precursor protein in brain and platelets. Journal of Neuroscience Research, 74:386-392.
  8. Evin G, Holsinger RMD, Eggert S, Weidemann A, Canterford L, Hoke D, Gandy S, McLean C, Beyreuther K and Masters CL. (2002) Carboxyl-terminal fragments of the amyloid precursor protein in Alzheimer's disease brain: detection of γ-secretase products. Brain Aging, 2(3):61-66.
  9. Holsinger RMD, McLean CA, Beyreuther K, Masters CL and Evin G. (2002) Increased expression of the amyloid precursor β-secretase in Alzheimer's Disease. Annals of Neurology, 51:783-786.
  10. Fahnestock M, Garzon D, Holsinger RMD and Michalski B. (2002) Neurotrophic factors and Alzheimer's disease: are we focusing on the wrong molecule? Journal of Neural Transmission (Suppl.), 62:239-250.
  11. Evin G, Sharples RA, Weidemann A, Reinhard FB, Carbone V, Culvenor JG, Holsinger RMD, Sernee MF, Beyreuther K and Masters CL. (2001) Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease. Biochemistry, 40(28):8359-8368.
  12. Holsinger RMD, Schnarr J, Henry P, Castelo, VT and Fahnestock M. (2000) Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease. Molecular Brain Research, 76(2):347-354.
  13. Ferbinteanu J, Holsinger RMD, McDonald RJ. (1999) Lesions of the medial or lateral perforant path have different effects on hippocampal contributions to place learning and fear conditioning to context. Behavioural Brain Research, 101: 65-84.
  14. Ikeda-Douglas CJ, Head E, Holsinger RMD, Tremblay L, Racine RJ, Milgram NW. (1998) Selective loss of early suppression in the dentate gyrus precedes kainic acid induced electrographic seizures. Epilepsy Research, 31: 143-152.
  15. Michael M, Holsinger D, Ikeda-Douglas C, Cammisuli S, Ferbinteanu J, D'Souza C, D'Souza S, Fecteau J, Racine RJ, Milgram NW. (1998) Development of spontaneous seizures over extended kindling: I. Electrographic, behavioral, and transfer kindling correlates. Brain Research, 793: 197-211.
  16. Cammisuli S, Murphy MP, Ikeda-Douglas CJ, Balkissoon V, Holsinger RMD, Head E, Michael M, Racine RJ, Milgram NW. (1997) Effects of extended kindling on exploratory behavior and spatial learning. Behavioural Brain Research, 89(1-2): 179-190.