Dr Damian Holsinger

Lecturer in Neuroscience Biomedical Sciences, School of Medical Sciences M02 - Mallet Street Campus The University of Sydney NSW 2006 Australia T: +61 2 9351 9324 (or 0876) F: +61 2 9351 9520 E:

Biographical details

Damian Holsinger began investigating molecular mechanisms underlying Alzheimer's disease in 1997. In 2002 he made the seminal discovery that levels of the pivotal AD-related enzyme, BACE1, were increased in the brain of patients. These findings have been widely accepted in the field and have led to a concentrated focus on this enzyme as a therapeutic avenue for the treatment of Alzheimer’s disease. In 2006, Damian accepted a position as Lecturer in Neuroscience at The University of Sydney and founded the Laboratory of Molecular Neuroscience at the Brain & Mind Research Institute in 2007. He continues to investigate molecular mechanisms underlying neurodegenerative diseases with a particular focus on BACE1.

Research interests

Research interests surround the understanding of mechanisms by which complex neurological disorders arise and methods of treating these diseases.

Current national competitive grants*

2009

in vivo regulation of the Alzheimers disease beta-secretase, BACE1
Holsinger D
NHMRC Project Grants ($277,000 over 3 years)

* Grants administered through the University of Sydney